Recent Publications

BDNF Signaling in Glutamatergic Neurons During Long-Term Potentiation (LTP): A Spatio-Temporal Exploration of Events. K. Mohandas, R. Rishikesh, R, Y.M. Balan, A. Deepti, S. Hosseini, M. Korte., & B.C.P. Sasidharan. (2025). Molecular Neurobiology, 1-19.

Remodelling the gut ecosystem: a dysbiosis model to elucidate gut-organ axis dynamics in mice, Krishnapriya, Dayamrita Kollaparampil Kishanchand, Rishikesh, Siddarthan Venkatachalam, Aneesa Painadath Alikunju, Ayswaria Deepti, Unnikrishnan Sivan, Baby Chakrapani Pulikkaparambil Sasidharan, Physiology & Behavior, Vol. 299, 1 October 2025, 115000.

Artificial blue light exposure induces anxiety-like behaviour, alters recognition memory and modifies hippocampal morphology in adolescent rats. Iffath Ahmed, Roshan Atif Bashir Eltayeb, Hamdan Iftikhar Siddiqui, Yadukrishnan Moothedath Balan, Baby Chakrapani P. S, Sareesh Naduvil Narayanan, Neuroscience and Behavioral Physiology, March 2025.

Co-delivery of curcumin-resveratrol-carnosic acid complex promotes neurogenesis and cognitive recovery in a rodent model of repeated mild traumatic brain injury. Mohind C Mohan, AS Anjana, TA Hilmi Jaufer, Ayswaria Deepti, IM Krishnakumar, Baby Chakrapani P. S, Biomedicine & Pharmacotherapy, February 5, 2025, Volume 183, Pages 117818.

Investigation to Understand the Role of Phase Variation in Red Emitting Eu3+-Doped Calcium Magnesium Silicate Phosphor for In Vitro Bioimaging. Navya Sara Kuriyan, Ayswaria Deepti,Baby Chakrapani P. S, Sabeena Mannilthodi, ACS Applied Bio Materials, Vol 8/Issue 2, February 5, 2025.

Luminescent Tb3+/Sm3+ co-doped hydroxyapatite nanoparticles as an imaging probe in N2a cells. Pooja Gitty, Ayswaria Deepti, P Prabeesh, AS Anjana, EI Anila, Kamal P Mani, Baby Chakrapani P. S, VPN Nampoori, M Kailasnath. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Volume 327, 15 February 2025, 125334.

The Intricate Interplay: Microbial Metabolites and the Gut-Liver-Brain Axis in Parkinson's Disease. Dayamrita Kollaparampil Kishanchand, Athira Krishnan K. A., Krishnapriya Chandrababu, Cyriac Abby Philips, Unnikrishnan Sivan, Baby Chakrapani Pulikaparambil Sasidharan. 03 January 2025, Volume 103, Issue 1, Pages e70016.

Fluorescence bioimaging applications of europium-doped strontium aluminate nanoparticles. Neenu Mary Thomas, Naijil George, MO Viji, KC Bins, Baby Chakrapani P. S, EI Anila. Ceramics International. Available online 14 December 2024.

Microbial consortia-derived cellulose biomaterial: Synthesis, characterization, and utility in neural tissue regeneration. Sharrel Rebello, Anila Deepak, Krishnapriya Chandrababu, EM Aneesh, PS Baby Chakrapani, MS Jisha. International Journal of Biological Macromolecules. Volume 288, February 2025, 138719.

Neurological, psychological, psychosocial complications of long-COVID and their management. Sareesh Naduvil Narayanan, Sreeshma Padiyath, Krishnapriya Chandrababu, Lima Raj,Baby Chakrapani P. S, George Abraham Ninan, Ajith Sivadasan, Alexander Ryan Jacobs, Yan Wa Li, Anand Bhaskar. Neurological Sciences. November 2024.

Transcriptomic analysis of CNTF-treated mouse subventricular zone-derived neurosphere culture reveals key transcription factor genes related to adult neurogenesis. Bins Kathanadan Chackochan, Sinoy Johnson, Hilmi Jaufer Thameemul Ansari, Ajith Vengellur, Unnikrishnan Sivan, Sayuj Koyyappurath,Baby Chakrapani P. S. Heliyon. Volume 10, Issue 19, 15 October 2024, e38496.

An easy and cost-effective method for the isolation and culturing of Neural Stem/ Progenitor cells from the Subventricular (SVZ) and Dentate Gyrus (DG) of Adult Mouse Brain. Ayswaria Deepti, Bins Kathanadan Chackochan, Sreelakshmi Sadanandan, Anagha Sunilkumar Menon, Krishnakumar Mohandas, Ajith Vengellur, Unnikrishnan Sivan, Pulikkaparambil Sasidharan Baby Chakrapani. Journal of Neuroscience Methods. Available online 19 January 2024, 110060.

Exploring the short-term influence of a proprietary oil extract of black cumin (Nigella sativa) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study. ME Mohan, Mohind C Mohan, Prathibha Prabhakaran, S Syam Das, IM Krishnakumar, Baby Chakrapani P. S. Frontiers in Nutrition. February 2024. Volume 11.

Unravelling the Parkinson's Puzzle: From Medications and Surgery to Stem Cells and Genes – A Comprehensive Review of Current and Future Management Strategies. Krishnapriya Chandrababu, Vineeth Radhakrishnan, Anjana A.S., Rahul Rajan, Unnikrishnan Sivan, Syam Krishnan, Baby Chakrapani P.S. Exp Brain Res. January 2024.

Exploring the short-term influence of a proprietary oil extract of black cumin (Nigella sativa) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study. M. E. Mohan, Mohind C. Mohan, Prathibha Prabhakaran, S. Syam Das, I. M. Krishnakumar and P. S. Baby Chakrapani. Frontiers in Nutrition, January 2024.

Protection by Nano-Encapsulated Bacoside A and Bacopaside I in Seizure Alleviation and Improvement in Sleep-In Vitro and In Vivo Evidences. C. Sekhar, V., Gulia, K. K., Deepti, A., Chakrapani, P. B., Baby, S., & Viswanathan, G. Mol Neurobiol. (2024).

Biocompatible, Europium-Doped Fluorapatite Nanoparticles as a Wide-Range pH Sensor. Krishnapriya, T. K., Ayswaria Deepti, P S Baby Chakrapani, A. S. Asha, and M.K.Jayaraj. Journal of Fluorescence (2023), pp.1-13.

Structural and biological properties of novel Vanadium and Strontium co-doped HAp for tissue engineering applications. Megha, M., Anjumol Joy, Gayathri Unnikrishnan, M. Haris, Jibu Thomas, Ayswaria Deepti, PS Baby Chakrapani, Elayaraja Kolanthai, and Senthilkumar Muthuswamy. Ceramics International 49, no. 18 (2023): 30156-30169.

Influence of CurQfen®-curcumin on cognitive impairment: a randomized, double-blinded, placebo-controlled, 3-arm, 3-sequence comparative study. S. Syam Das, Prasad M. Gopal, Jestin V. Thomas, Mohind C. Mohan, Siju C. Thomas, Balu P. Maliakel, I. M. Krishnakumar and Baby Chakrapani Pulikkaparambil Sasidharan. Frontiers in Dementia, September 2023, 2, 1222708.

A novel combination of graphene oxide/palladium integrated polycaprolactone nanocomposite for biomedical applications. Anjumol Joy, Gayathri Unnikrishnan, M. Megha, M. Haris, Jibu Thomas, Ayswaria Deepti, P.S. Baby Chakrapani, Elayaraja Kolanthai, Senthilkumar Muthuswamy. Diamond and Related Materials, Volume 136, June 2023, 110033.

Mulberry Leaves (Morus Rubra)-Derived Blue-Emissive Carbon Dots Fed to Silkworms to Produce Augmented Silk Applicable for the Ratiometric Detection of Dopamine. Varsha Lisa John, A. R. Nayana, T. R. Keerthi, Athira Krishnan K. A., B. C. P. Sasidharan, and Vinod T. P. Macromol. Biosci. 2023 Apr 25;e2300081.

A proprietary black cumin oil extract (Nigella sativa) (BlaQmax®) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study. Muttanahally Eraiah Mohan, Jestin V. Thomas, Mohind C. Mohan, Syam Das S, Prathibha Prabhakaran and Baby Chakrapani Pulikkaparambil Sasidharan. Frontiers in Nutrition, April 2023.

Efficient Generation of Tyrosine Hydroxylase-Expressing Dopamine-Producing Neurons from Rat Peripheral Blood Progenitors Using a Combination of Growth Factors and Biomimetic Matrix. Prabha Prakash, Rahul Rajan, Ayswaria Deepti, Ajith Vengellur, Unnikrishnan Sivan,Baby Chakrapani P. S. Arch Clin Biomed Res, Volume 7, Issue 2, March 2023.

Biological and Sensing Applications of a Few 1,3,4-Oxadiazole Based Donor-Acceptor Systems. T. M. Remya, T. M. Asha, Ayswaria Deepti, Prakash Prabha, P. S. Baby Chakrapani, P. A. Unnikrishnan, Abdullah G Al-Sehemi. Journal of Fluorescence, Published Online; March 2023.

Ultrafast detection of folic acid in nanomolar levels and cancer cell imaging using hydrothermally synthesized carbon dots. T.K. Krishnapriya, S. Prasanth, Ayswaria Deepti, P.S. Baby Chakrapani, A.S. Asha, M.K. Jayaraj. Microchemical Journal, Volume 188, May 2023, 108470.

A Multi-Stimuli responsive organic luminogen with aggregation induced emission for the selective detection of Zn2+ ions in solution and solid state. Francis Joy K.P., Chaithra, Aatika Nizam, Ayswaria Deepti, P.S. Baby Chakrapani, Avijit Kumar Das, T.P. Vinod, Yamuna Nair. Chemical Engineering Journal, Volume 453, Part 2, 1 February 2023, 139798.

Thymoquinone-rich black cumin oil improves sleep quality, alleviates anxiety/stress on healthy subjects with sleep disturbances–A pilot polysomnography study. SyamDas, S., Kannan, R., George, S., Baby Chakrapani Pulikkaparambil Sasidharan, Maliakel, B., Ittiyavirah, S., & Krishnakumar, I. M. Journal of Herbal Medicine, 32, 100507 (2022).

Anti-excitotoxicity and neuroprotective action of asiaticoside encapsulated polymeric nanoparticles in pilocarpine rodent seizure model. Renju Kunjumon, Gayathri Viswanathan, Devi Velayudhan Jayasree, Prabath Gopalakrishnan Biju, Prabha Prakash, Baby Chakrapani Pulikkaparambil Sasidharan, Sabulal Baby. Canadian Journal of Chemistry, 31 January 2022.

Structural and optical properties of dysprosium-doped hydroxyapatite nanoparticles and the use as a bioimaging probe in human cells. Pooja Gitty, Kamal Planthadathil Mani, Ayswaria Deepti, Pulikkaparambil Sasidharan Baby Chakrapani, Punathil Prabeesh, Vadakkedathu Parameswaran Narayanan Nampoori, Madanan Kailasnath. Luminescence, Volume 37, Issue 5 p. 758-765. February 2022.

Radio frequency plasma assisted surface modification of Fe3O4 nanoparticles using polyaniline/polypyrrole for bioimaging and magnetic hyperthermia applications. Beena Mol, Ansar Ereath Beeran, Prasad S. Jayaram, Prabha Prakash, Ramapurath S. Jayasree, Senoy Thomas, Baby Chakrapani , M. R. Anantharaman, M. Junaid Bushiri. Journal of Materials Science: Materials in Medicine (2021) 32:108.

Eggshell Derived Europium Doped Hydroxyapatite Nanoparticles for Cell Imaging Application. T K Krishnapriya, Ayswaria Deepti, P S Baby Chakrapani, A S Asha, M K Jayaraj. J Fluoresc. 2021 Nov;31(6):1927-1936.

Plant derived bioactive compounds and their potential to enhance adult neurogenesis. Krishnapriya, Parameswaran Sasikumar, Maniyamma Aswathy, Prakash Tripathi Prem, Kokkuvayil Vasu Radhakrishnan, Pulikkaparambil Sasidharan Baby Chakrapani. Phytomedicine Plus. Volume 2, Issue 1, February 2022, 100191.

Natural self-emulsifying reversible hybrid-hydrogel delivery (N'SERH) of tocopherol enhances bioavailability and modulates alcohol-induced reproductive toxicity in rats. Vismaya, K. U., Noorjasmine, T. N., Syam Das, S., Kesavan, L., Baby Chakrapani, P. S., Krishnakumar, I. M., & Kumar, C. V. S. Andrologia, Dec 2021, e14305.

Enhanced absorption of curcuminoids and 3-Acetyl-11-keto-β-boswellic acid from fenugreek galactomannan hydrogel beadlets: A natural approach to the co-delivery of lipophilic phytonutrients. M.B. Abhilash, Dinesh Kumar, Ayswarya Deepti, Aswathi Nair, Vanheule Greet, Vynckier An-Katrien, Van Den Driessche Mieke, Syam Das Sivadasan, Balu Maliakel, Baby Chakrapani, Krishnakumar IM. Journal of Functional Foods. Volume 79, April 2021, 104405.

Madecassoside encapsulated in alginate chitosan nanoparticles exerts anti-excitotoxicity effects in pilocarpine-induced seizure. Renju Kunjumon, Gayathri Viswanathanan, Devi Velayudhan Jayasree, Prabath Gopalakrishnan Biju, Prabha Prakash, Baby Chakrapani Pulikkaparambil Sasidharan, Sabulal Baby. Phytomedicine Plus Volume 1, Issue 1, February 2021, 100004.

Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders. Sreyashi Chandra, Md Tanjim Alam, Jhilik Dey, Baby Chakrapani P S, Upasana Ray, Amit Kumar Srivastava, Sonu Gandhi Prem Prakash Tripathi. Curr Top Med Chem. 2020;20(13):1142-1153.

A tale of two patients: Levodopa and creative awakening in Parkinson's disease - A qualitative report. Chacko J, George S, Cyriac S, Chakrapani B. Asian J Psychiatr. 2019, Jun 13; 43:179-181.

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Nordstrom U, Beauvais G, Ghosh A, Pulikkaparambil Sasidharan BC, Lundblad M, Fuchs J, Joshi RL, Lipton JW, Roholt A, Medicetty S, Feinstein TN, Steiner JA, Escobar Galvis ML, Prochiantz A, & Brundin P. Neurobiol Dis, 73: 70–82 (2015).

Neurogenesis in the Dentate Gyrus Depends on CNTF and STAT3 Signaling. Müller S, Chakrapani BP, Schwegler H, Hofmann HD, Kirsch M. Stem Cells, Volume 27, Issue 2, February 2009, Pages 431–441.

Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. Chakrapani BP, Kumar S, Subramaniam JR. J Biosci. 2008 Jun; 33(2):269-77.